The purpose of this paper is to define the existence of crime against cultural heritage and determine whether this type of criminality is on the rise around the world. By carrying out guided interviews with experts in this field, the authors wished to define guidelines for the fight against this type of criminality. By studying the available literature, the authors found that crime against cultural heritage is on the rise. Economically and socially less-developed countries, from which most antiquities originate, are most susceptible to this type of criminality. Such countries of origin include particularly the countries of South America and the Middle East, while the Western part of the globe is mainly market-oriented and represents the final destination of smuggled antiquities. This paper also aims to determine the adequacy and appropriateness of legal acts governing the protection of cultural heritage and the fight against this type of criminality. Problems are mainly related to the implementation and enforcement of such legal provisions and related sanctions in practice.